Induction of preprotachykinin-I and neurokinin-1 by adrenocorticotropin and prolactin. Implication for neuroendocrine-immune-hematopoietic axis

J Neuroimmunol. 2001 Jan 1;112(1-2):188-96. doi: 10.1016/s0165-5728(00)00405-7.

Abstract

We studied the complex interactions within the neuroendocrine-immune-hematopoietic axis by determining a possible link among ACTH, PRL, PPT-I and the receptors for its peptides, NK-1 and NK-2. Indeed, ACTH and PRL induced the expression of PPT-I and NK-1 in human bone marrow stroma with no effect on NK-2. Consistent with a role for PPT-I in regulating the development of myeloid and erythroid progenitors, we found that ACTH and PRL, through NK-1 stimulated the proliferation of both types of progenitors. Induction of PPT-I was regulated at the transcriptional and post-transcriptional levels. The results showed that ACTH and PRL stimulated the proliferation of bone marrow progenitors, partly through PPT-I and NK-1 induction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenocorticotropic Hormone / pharmacology*
  • Bone Marrow / metabolism
  • Gene Expression Regulation / drug effects*
  • Hematopoietic Stem Cells / drug effects*
  • Humans
  • Prolactin / pharmacology*
  • Protein Precursors / biosynthesis*
  • Protein Precursors / genetics
  • RNA, Messenger / analysis
  • Stromal Cells / metabolism
  • Tachykinins / biosynthesis*
  • Tachykinins / genetics
  • Transcription, Genetic

Substances

  • Protein Precursors
  • RNA, Messenger
  • Tachykinins
  • preprotachykinin
  • Adrenocorticotropic Hormone
  • Prolactin