Abstract
We describe the first reported human immunodeficiency virus (HIV)-seronegative patient treated with cidofovir for progressive multifocal leukoencephalopathy (PML). Marked clinical and radiological progression of PML occurred during cidofovir therapy. The improvement observed during cidofovir therapy of HIV-infected patients may be due to the effect of concomitant antiretroviral therapy rather than cidofovir.
MeSH terms
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Anti-HIV Agents / therapeutic use*
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Brain / pathology
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Cidofovir
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Cytosine / analogs & derivatives
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Cytosine / therapeutic use*
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Female
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HIV Infections
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Humans
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Leukoencephalopathy, Progressive Multifocal / drug therapy*
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Leukoencephalopathy, Progressive Multifocal / pathology
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Magnetic Resonance Imaging / methods
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Middle Aged
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Organophosphonates*
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Organophosphorus Compounds / therapeutic use*
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Treatment Failure
Substances
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Anti-HIV Agents
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Organophosphonates
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Organophosphorus Compounds
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Cytosine
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Cidofovir