Abstract
Early death in Schimke immuno-osseous dysplasia often results from renal failure and/or cell-mediated immunodeficiency. Kidney transplants have improved renal function, but effective therapy for the immunodeficiency has not yet been reported. We describe markedly improved marrow function 2 years after bone marrow transplantation in a boy with Schimke immunoosseous dysplasia.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antigens, CD / blood
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Bone Marrow Transplantation*
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Child
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Child, Preschool
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Graft vs Host Disease / prevention & control
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Humans
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Immunosuppressive Agents / therapeutic use
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Infant, Newborn
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Kidney Transplantation
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Lymphopenia / complications
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Lymphopenia / diagnosis
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Male
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Osteochondrodysplasias / complications
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Osteochondrodysplasias / genetics*
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Osteochondrodysplasias / therapy*
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Pedigree
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Renal Insufficiency / complications
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Renal Insufficiency / surgery
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Tacrolimus / therapeutic use
Substances
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Antigens, CD
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Immunosuppressive Agents
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Tacrolimus