A natural history of melanoma: serial gene expression analysis

Immunol Today. 2000 Dec;21(12):619-23. doi: 10.1016/s0167-5699(00)01724-2.

Abstract

Ena Wang and Francesco Marincola propose a novel strategy whereby tumor-host interactions are studied within the melanoma microenvironment by serial gene expression analysis. Methodological constraints and ways to circumvent them are discussed. This approach might improve our understanding of the molecular basis of tumor regression in response to immune manipulation.

Publication types

  • Review

MeSH terms

  • Alleles
  • Antigens, Neoplasm / biosynthesis
  • Antigens, Neoplasm / genetics
  • Antigens, Neoplasm / immunology
  • Biopsy, Needle
  • DNA, Neoplasm / genetics
  • Disease Progression
  • Gene Expression Profiling*
  • Gene Expression Regulation, Neoplastic*
  • Human Genome Project
  • Humans
  • Immune Tolerance
  • Melanoma / genetics*
  • Melanoma / immunology
  • Melanoma / metabolism
  • Melanoma / pathology
  • Neoplasm Proteins / biosynthesis
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / immunology
  • Oligonucleotide Array Sequence Analysis
  • T-Lymphocytes, Cytotoxic / immunology

Substances

  • Antigens, Neoplasm
  • DNA, Neoplasm
  • Neoplasm Proteins