The biochemical profile of rat testicular tissue as measured by magic angle spinning 1H NMR spectroscopy

FEBS Lett. 2000 Dec 15;486(3):225-9. doi: 10.1016/s0014-5793(00)02307-3.

Abstract

The testis is the principal organ of male fertility, responsible for the production of spermatozoa and their maturation into sperm. However, the underlying biochemistry of the testis is relatively understudied. The fluidic and homogeneous nature of the testis makes it an ideal organ for high resolution magic angle spinning (MAS) 1H NMR spectroscopy. In this study we have catalogued the low molecular weight metabolites. The testis contains large amounts of creatine, of which a substantial proportion was shown to be extracellular using bipolar gradients to measure apparent diffusion coefficients. The tissue also contained relatively high amounts of uridine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine / analysis
  • Animals
  • Choline / analysis
  • Creatine / analysis
  • Diffusion
  • Extracellular Space / chemistry
  • Intracellular Fluid / chemistry
  • Lactic Acid / analysis
  • Magnetic Resonance Spectroscopy* / methods
  • Male
  • Phosphatidylcholines / analysis
  • Rats
  • Testis / chemistry*
  • Uridine / analysis
  • Water / analysis

Substances

  • Phosphatidylcholines
  • Water
  • Lactic Acid
  • Creatine
  • Choline
  • Alanine
  • Uridine