The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene

F Mugneret; M Chaffanet; M Maynadié; G Guasch; B Favre; O Casasnovas; D Birnbaum; M J Pébusque

doi:10.1046/j.1365-2141.2000.02355.x

The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene

Br J Haematol. 2000 Nov;111(2):647-9. doi: 10.1046/j.1365-2141.2000.02355.x.

Authors

F Mugneret¹, M Chaffanet, M Maynadié, G Guasch, B Favre, O Casasnovas, D Birnbaum, M J Pébusque

Affiliation

¹ Laboratoires de Cytogénétique et d'Hématologie, Hématologie clinique, Hôpital du Bocage, Dijon, France.

PMID: 11122115
DOI: 10.1046/j.1365-2141.2000.02355.x

Abstract

Translocations affecting the chromosomal locus 8p12 are hallmarks of an atypical stem cell myeloproliferative disorder. These events disrupt the fibroblast growth factor receptor 1 (FGFR1) gene and fuse the FGFR1 C-terminus catalytic domain with unrelated proteins. Here, we report on the characterization of the 19q13.3 locus as the fifth FGFR1 chromosomal partner.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Chromosomes, Human, Pair 19*
Chromosomes, Human, Pair 8*
Humans
In Situ Hybridization, Fluorescence
Male
Myeloproliferative Disorders / genetics*
Receptor Protein-Tyrosine Kinases / genetics*
Receptor, Fibroblast Growth Factor, Type 1
Receptors, Fibroblast Growth Factor / genetics*
Translocation, Genetic*

Substances

Receptors, Fibroblast Growth Factor
FGFR1 protein, human
Receptor Protein-Tyrosine Kinases
Receptor, Fibroblast Growth Factor, Type 1