Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

J Immunol. 2001 Jan 1;166(1):15-9. doi: 10.4049/jimmunol.166.1.15.

Abstract

Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the inflammatory response to lipoteichoic acid, lipopeptides, and glycans from a variety of microbes, whereas TLR4 is essential for a complete response to LPSs. We report here that TLR2 transduces the response to phenol-soluble modulin, a factor secreted by Staphylococcus epidermidis. The TLR2-mediated response to this modulin was enhanced by TLR6 but inhibited by TLR1, indicating a functional interaction between these receptors. We also demonstrate that a response to phenol-soluble modulin mediated by TLR2 and TLR6 was more refractory to inhibition by TLR1 than one mediated by TLR2 alone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / physiology*
  • Bacterial Toxins / antagonists & inhibitors
  • Bacterial Toxins / metabolism*
  • Cell Line
  • Cloning, Molecular
  • Drosophila Proteins*
  • Extracellular Space / immunology
  • Humans
  • Membrane Glycoproteins / antagonists & inhibitors
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / metabolism
  • Membrane Glycoproteins / physiology*
  • Mice
  • Mice, Inbred C3H
  • Molecular Sequence Data
  • Phenols
  • Protein Structure, Tertiary / genetics
  • Protein Structure, Tertiary / physiology
  • Receptors, Cell Surface / antagonists & inhibitors
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism
  • Receptors, Cell Surface / physiology*
  • Solubility
  • Staphylococcus epidermidis / immunology*
  • Toll-Like Receptor 1
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Toll-Like Receptor 6
  • Toll-Like Receptors
  • Transfection

Substances

  • Bacterial Proteins
  • Bacterial Toxins
  • Drosophila Proteins
  • Membrane Glycoproteins
  • Phenols
  • Receptors, Cell Surface
  • TLR2 protein, human
  • TLR4 protein, human
  • TLR6 protein, human
  • Tlr6 protein, mouse
  • Toll-Like Receptor 1
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Toll-Like Receptor 6
  • Toll-Like Receptors
  • staphylococcal delta toxin

Associated data

  • GENBANK/AY009154