At this juncture, many important questions still need to be answered about the prevention and treatment of CAD in women. It is clear that modification of traditional risk factors, including treatment of hypertension, cessation of smoking, and treatment of hypercholesterolemia, can lead to a decrease in coronary events and, hopefully, in total mortality in women. Both statin drugs and estrogen replacement therapy offer benefits in many instances. For now, use of HRT remains a personal decision that every postmenopausal woman needs to carefully consider and discuss with her physician.