2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1

S Sarshar; C Zhang; E J Moran; S Krane; J C Rodarte; K D Benbatoul; R Dixon; A M Mjalli

doi:10.1016/s0960-894x(00)00520-5

2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1

Bioorg Med Chem Lett. 2000 Dec 4;10(23):2599-601. doi: 10.1016/s0960-894x(00)00520-5.

Authors

S Sarshar¹, C Zhang, E J Moran, S Krane, J C Rodarte, K D Benbatoul, R Dixon, A M Mjalli

Affiliation

¹ Ontogen Corporation, Carlsbad, CA 92009, USA. [email protected]

PMID: 11128632
DOI: 10.1016/s0960-894x(00)00520-5

Abstract

N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-glycoprotein mediated multidrug resistance. This manuscript describes the discovery and lead optimization of this novel class of inhibitors.

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects*
ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology
Drug Resistance, Multiple*
Imidazoles / pharmacology*

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Imidazoles