2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 2

C Zhang; S Sarshar; E J Moran; S Krane; J C Rodarte; K D Benbatoul; R Dixon; A M Mjalli

doi:10.1016/s0960-894x(00)00521-7

2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 2

Bioorg Med Chem Lett. 2000 Dec 4;10(23):2603-5. doi: 10.1016/s0960-894x(00)00521-7.

Authors

C Zhang¹, S Sarshar, E J Moran, S Krane, J C Rodarte, K D Benbatoul, R Dixon, A M Mjalli

Affiliation

¹ Ontogen Corporation, Carlsbad, CA 92009, USA.

PMID: 11128633
DOI: 10.1016/s0960-894x(00)00521-7

Abstract

Solution-phase combinatorial chemistry was applied to the optimization and development of clinical candidate OC144-093 (22), a novel and nontoxic modulator of P-glycoprotein mediated multidrug resistance.

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects*
Combinatorial Chemistry Techniques
Drug Resistance, Multiple*
Half-Life
Humans
Imidazoles / chemistry
Imidazoles / pharmacokinetics
Imidazoles / pharmacology*
Male
Molecular Structure
Reference Values

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Imidazoles