Improved synthesis of the iodine-free thyromimetic GC-1

G Chiellini; N H Nguyen; H A Yoshihara; T S Scanlan

doi:10.1016/s0960-894x(00)00531-x

Improved synthesis of the iodine-free thyromimetic GC-1

Bioorg Med Chem Lett. 2000 Dec 4;10(23):2607-11. doi: 10.1016/s0960-894x(00)00531-x.

Authors

G Chiellini¹, N H Nguyen, H A Yoshihara, T S Scanlan

Affiliation

¹ Department of Pharmaceutical Chemistry, University of California, San Francisco 94143-0446, USA.

PMID: 11128634
DOI: 10.1016/s0960-894x(00)00531-x

Abstract

Synthesis of the TRbeta-selective thyromimetic GC-1 has been improved using methoxymethyl (MOM) and triisopropylsilyl (TiPS) substituents as phenolic protecting groups. The new synthetic route is adaptable to analogue design.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Iodine / chemistry*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Mimicry
Thyroid Hormones / chemical synthesis*
Thyroid Hormones / chemistry

Substances

Thyroid Hormones
Iodine

Grants and funding

DK 52798/DK/NIDDK NIH HHS/United States