6-Hydroxy-1,3-dioxin-4-ones as non-peptidic HIV protease inhibitors

Y S Lee; Y S Lee; J Y Lee; S N Kim; C K Lee; H Park

doi:10.1016/s0960-894x(00)00534-5

6-Hydroxy-1,3-dioxin-4-ones as non-peptidic HIV protease inhibitors

Bioorg Med Chem Lett. 2000 Dec 4;10(23):2625-7. doi: 10.1016/s0960-894x(00)00534-5.

Authors

Y S Lee¹, Y S Lee, J Y Lee, S N Kim, C K Lee, H Park

Affiliation

¹ Division of Life Sciences, Korea Institute of Science & Technology, Cheongryang, Seoul, South Korea.

PMID: 11128638
DOI: 10.1016/s0960-894x(00)00534-5

Abstract

HIV protease inhibitors containing 6-hydroxy-1,3-dioxin-4-one ring system as a new scaffold have been prepared. Among them, compound 4d showed potent HIV protease inhibitory activity (IC50 = 0.01 microM) and antiviral activity in cell culture (EC50 = 0.96 microM, SI = 65.69).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology*
Cells, Cultured
Dioxins / chemistry
Dioxins / pharmacology*
HIV Protease Inhibitors / chemistry
HIV Protease Inhibitors / pharmacology*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests

Substances

Anti-HIV Agents
Dioxins
HIV Protease Inhibitors