Abstract
6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of beta-lactamases, enzymes of resistance for beta-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of beta-lactamases.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Drug Design
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Molecular Probes*
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Penicillanic Acid / analogs & derivatives*
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Penicillanic Acid / chemistry
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Penicillanic Acid / metabolism
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Penicillanic Acid / pharmacology
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Substrate Specificity
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beta-Lactamase Inhibitors
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beta-Lactamases / chemistry
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beta-Lactamases / metabolism*
Substances
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Enzyme Inhibitors
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Molecular Probes
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beta-Lactamase Inhibitors
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Penicillanic Acid
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beta-Lactamases