Effect of subthalamic nucleus stimulation on levodopa-induced dyskinesia in Parkinson's disease

Neurology. 2000 Dec 26;55(12):1921-3. doi: 10.1212/wnl.55.12.1921.

Abstract

Article abstract-The authors studied the effect of bilateral subthalamic nucleus stimulation on levodopa-induced dyskinesias in 24 consecutive parkinsonian patients with disabling dyskinesias. The improvement in the three subtypes of levodopa-induced dyskinesias was significant from the third postoperative month and was mainly due to the decrease in the daily dose of levodopa allowed by the stimulation-induced improvement in the motor score.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Dyskinesia, Drug-Induced / etiology*
  • Electric Stimulation
  • Female
  • Humans
  • Levodopa / adverse effects
  • Levodopa / therapeutic use*
  • Male
  • Middle Aged
  • Parkinson Disease / therapy*
  • Thalamic Nuclei / physiopathology*

Substances

  • Levodopa