Early neonatal brain injury in histologic chorioamnionitis

De Felice C; P Toti; R N Laurini; M Stumpo; E Picciolini; T Todros; P Tanganelli; G Buonocore; R Bracci

doi:10.1067/mpd.2001.109605

Early neonatal brain injury in histologic chorioamnionitis

J Pediatr. 2001 Jan;138(1):101-4. doi: 10.1067/mpd.2001.109605.

Authors

De Felice C¹, P Toti, R N Laurini, M Stumpo, E Picciolini, T Todros, P Tanganelli, G Buonocore, R Bracci

Affiliation

¹ Department of Preventive Pediatrics and Neonatology, the Institute of Pathology, University of Siena, Siena, Italy.

PMID: 11148520
DOI: 10.1067/mpd.2001.109605

Abstract

The relation between clinical or histologic chorioamnionitis and early neonatal adverse neurologic outcome was investigated (n = 483). Histologic, but not clinical, evidence of chorioamnionitis was found to be a significant predictor of periventricular echodensity (odds ratio, 2.4; 95% CI, 1.8-3.2), echolucency (3.3; 1.9-5.6), ventriculomegaly (2.7; 1.8-4.2), intraventricular hemorrhage > or =3 (3.5; 2.4-5.2), and seizures (2.3; 1.4-3.7).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Brain Injuries / diagnostic imaging
Brain Injuries / etiology*
Cerebral Ventricles / injuries*
Chorioamnionitis / complications*
Chorioamnionitis / pathology*
Female
Histological Techniques / standards*
Humans
Infant, Newborn
Intracranial Hemorrhages / diagnostic imaging
Intracranial Hemorrhages / etiology*
Leukomalacia, Periventricular / diagnostic imaging
Leukomalacia, Periventricular / etiology*
Logistic Models
Male
Multivariate Analysis
Odds Ratio
Placenta / pathology
Predictive Value of Tests
Pregnancy
Prospective Studies
Risk Factors
Seizures / diagnostic imaging
Seizures / etiology*
Sensitivity and Specificity
Single-Blind Method
Ultrasonography, Doppler, Transcranial