Abstract
The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cholinergic Fibers / drug effects
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Cholinergic Fibers / metabolism*
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Corpus Striatum / cytology
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism*
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Excitatory Amino Acid Agonists / pharmacology
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Excitatory Amino Acid Antagonists / pharmacology
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Glycine / analogs & derivatives
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Glycine / pharmacology
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In Vitro Techniques
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Interneurons / drug effects
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Interneurons / metabolism*
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Male
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Membrane Potentials / drug effects
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Phenylacetates / pharmacology
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Rats
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Rats, Wistar
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate / agonists
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Receptors, Metabotropic Glutamate / antagonists & inhibitors
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Receptors, Metabotropic Glutamate / biosynthesis*
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Resorcinols / pharmacology
Substances
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2-chloro-5-hydroxyphenylglycine
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Excitatory Amino Acid Agonists
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Excitatory Amino Acid Antagonists
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Grm5 protein, rat
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Phenylacetates
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate
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Resorcinols
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metabotropic glutamate receptor type 1
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3,5-dihydroxyphenylglycine
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Glycine