Oxidative degradation of pharmaceuticals: theory, mechanisms and inhibition

S Hovorka; C Schöneich

doi:10.1002/1520-6017(200103)90:3<253::aid-jps1>3.0.co;2-w

Oxidative degradation of pharmaceuticals: theory, mechanisms and inhibition

J Pharm Sci. 2001 Mar;90(3):253-69. doi: 10.1002/1520-6017(200103)90:3<253::aid-jps1>3.0.co;2-w.

Authors

S Hovorka¹, C Schöneich

Affiliation

¹ Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA.

PMID: 11170019
DOI: 10.1002/1520-6017(200103)90:3<253::aid-jps1>3.0.co;2-w

Abstract

Oxidation is a common pathway for drug degradation in liquid and solid formulations. The present article reviews mechanistic details of autoxidation and chain oxidation processes, as well as the oxidation of selected functional groups commonly affected in drugs.

Publication types

Review

MeSH terms

Oxidation-Reduction
Pharmaceutical Preparations / chemistry*
Reactive Oxygen Species

Substances

Pharmaceutical Preparations
Reactive Oxygen Species