Abstract
This study describes the antinociceptive activity of some N-aryl-glutaramic acids and N-aryl-glutarimides in writhing and formalin tests, two classical models of pain in mice. These compounds show high activity, being more active than acetyl salycilic acid, acetaminophen and indomethacin, used as standard drugs for comparison. The introduction of different substituent groups in the aromatic ring caused a significant change in activity. The results obtained here are promising from a pharmacological point of view, since these simple compounds might be used as models to obtain new and potent analgesic drugs.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetic Acid
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Analgesics / chemical synthesis*
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Analgesics / pharmacology
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Aspirin / pharmacology
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Chromatography, Thin Layer
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Formaldehyde
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Glutamic Acid / analogs & derivatives*
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Glutamic Acid / chemical synthesis
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Glutamic Acid / pharmacology
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Humans
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Indomethacin / pharmacology
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Magnetic Resonance Spectroscopy
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Muscle Contraction / drug effects
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Pain / chemically induced
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Pain / prevention & control
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Pain Measurement / drug effects
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Piperidones / chemical synthesis*
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Piperidones / pharmacology
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Analgesics
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Piperidones
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Formaldehyde
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Glutamic Acid
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Acetic Acid
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Aspirin
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Indomethacin