Genetic factors in the genesis of Alzheimer's disease

P H St George-Hyslop

doi:10.1111/j.1749-6632.2000.tb05552.x

Genetic factors in the genesis of Alzheimer's disease

Ann N Y Acad Sci. 2000:924:1-7. doi: 10.1111/j.1749-6632.2000.tb05552.x.

Author

P H St George-Hyslop¹

Affiliation

¹ Department of Medicine (Division of Neurology), University Health Network, University of Toronto, Toronto, Ontario, Canada M5S 3H2. [email protected]

PMID: 11193785
DOI: 10.1111/j.1749-6632.2000.tb05552.x

Abstract

At least four different genes have been identified that are associated with inherited susceptibiltiy to Alzheimer's disease. Some of the genes are highly penetrant (PS1, PS2, beta APP); the other, APOE, is a weaker susceptibility factor. Several additional genes are suspected to exist but have not yet been cloned.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / etiology
Alzheimer Disease / genetics*
Brain Chemistry / genetics*
Genetic Predisposition to Disease
Humans
Penetrance