[Radiotherapy of brain astrocytomas and oligodendrogliomas of the adult]

J J Mazeron; J M Simon; G Noël; M A Proudhom; A Renard

[Radiotherapy of brain astrocytomas and oligodendrogliomas of the adult]

Cancer Radiother. 2000 Nov:4 Suppl 1:53s-66s.

[Article in French]

Authors

J J Mazeron¹, J M Simon, G Noël, M A Proudhom, A Renard

Affiliation

¹ Centre des tumeurs, groupe hospitalier Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75651 Paris, France. [email protected]

PMID: 11194965

Abstract

Gliomas are moderately radiosensitive. The main prognostic factors are the anatomicopathological type and grade of glioma, the performance status, age of the patient and the extent of the surgery. According to data from the literature, high-grade gliomas should be given 60 Gy in five weekly fractions of 1.7 to 2 Gy in a volume including tumor or tumor bed, edema and a 2- to 3-cm margin. A dose of 45 Gy would be sufficient for low-grade gliomas, according to the results of a recent randomized EORTC trial. Brachytherapy and radiosurgery techniques may be indicated in selected cases.

Publication types

English Abstract
Review

MeSH terms

Adult
Astrocytoma / mortality
Astrocytoma / pathology
Astrocytoma / radiotherapy*
Brachytherapy / adverse effects
Brachytherapy / methods
Brain Neoplasms / mortality
Brain Neoplasms / pathology
Brain Neoplasms / radiotherapy*
Humans
Neutrons / therapeutic use
Oligodendroglioma / mortality
Oligodendroglioma / pathology
Oligodendroglioma / radiotherapy*
Photons / therapeutic use
Radiation Tolerance
Radiation-Sensitizing Agents / therapeutic use
Radiobiology
Radiotherapy Dosage
Randomized Controlled Trials as Topic
Stereotaxic Techniques

Substances

Radiation-Sensitizing Agents