Abstract
Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3'-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.
MeSH terms
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Animals
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Forkhead Transcription Factors
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Humans
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Mammals / physiology*
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Nuclear Proteins / metabolism*
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Phosphatidylinositol 3-Kinases / metabolism
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Phosphorylation
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Protein Serine-Threonine Kinases*
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / metabolism*
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Proto-Oncogene Proteins c-akt
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Signal Transduction / physiology*
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Transcription Factors / metabolism*
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Transcription, Genetic / physiology*
Substances
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Forkhead Transcription Factors
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MAS1 protein, human
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Nuclear Proteins
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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Transcription Factors
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AKT1 protein, human
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt