Staphylococcal surface display and its applications

Int J Med Microbiol. 2000 Dec;290(7):571-7. doi: 10.1016/s1438-4221(00)80002-8.

Abstract

Novel surface proteins can be introduced onto the bacterial cell surface by recombinant means. Here, we describe the development of such display systems for two food-grade bacteria, Staphylococcus carnosus and Staphylococcus xylosus, and present how such engineered bacteria can be used in different applications. A study will be described in which such staphylococci were employed as vaccine delivery vehicles to elicit protective antibody responses to respiratory syncytial virus (RSV). The use of surface-engineered staphylococci as novel microbial biocatalysts, as a new type of whole-cell diagnostic devices or for adsorption of metal ions with potential environmental or biosensor applications, will also be discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA, Bacterial
  • Drug Administration Routes
  • Enzymes / genetics
  • Enzymes / metabolism
  • Genetic Vectors* / genetics
  • Metals / metabolism
  • Mucous Membrane
  • Plasmids
  • Recombination, Genetic
  • Staphylococcus / genetics*
  • Vaccines, Synthetic

Substances

  • DNA, Bacterial
  • Enzymes
  • Metals
  • Vaccines, Synthetic