Type 2 diabetes mellitus in children: pathophysiology and risk factors

J Pediatr Endocrinol Metab. 2000:13 Suppl 6:1385-94. doi: 10.1515/jpem-2000-s612.

Abstract

Type 2 diabetes mellitus (DM) has been considered rare in the pediatric population. However, over the last decade, there has been a disturbing upswing in the rate of diagnosis of type 2 DM in the pediatric age group, mirroring the increasing rates of obesity in childhood. The pathophysiology of type 2 DM discussed in this article focuses on the delicate balance between insulin sensitivity and insulin secretion. The risk factors for youth-onset type 2 DM are presented, with careful evaluation of their impact on insulin sensitivity versus insulin secretion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acanthosis Nigricans / complications
  • Adolescent
  • Animals
  • Child
  • Diabetes Mellitus, Type 2 / etiology*
  • Diabetes Mellitus, Type 2 / genetics
  • Ethnicity
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Hyperandrogenism / complications
  • Hyperglycemia / complications
  • Insulin Resistance
  • Male
  • Obesity / complications
  • Polycystic Ovary Syndrome / complications
  • Puberty
  • Risk Factors