Abstract
Fractionated extracts of Feijoa peels were studied for cytotoxic activity, anti-human immunodeficiency virus (HIV) activity and antibacterial activity. Two most cytotoxic fractions A3 of acetone extract and M2 of methanol extract had potent inhibitory activity against Gram-positive and Gram-negative bacteria as well as fungi tested. Fraction A4 of acetone extract showed multidrug resistance (MDR)-reversal activity comparable with that of verapamil (positive control). These results indicate the therapeutic value of Feijoa peel extracts as potential antimicrobial and MDR-modulating agents.
MeSH terms
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / therapeutic use*
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Anti-HIV Agents / isolation & purification
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Anti-HIV Agents / therapeutic use*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Carcinoma, Squamous Cell / drug therapy
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Drug Evaluation, Preclinical / methods
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Humans
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Mouth Neoplasms / drug therapy
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Phytotherapy*
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Plant Extracts / therapeutic use*
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Plants, Edible / chemistry*
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Plants, Medicinal / chemistry*
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Tumor Cells, Cultured / drug effects
Substances
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Anti-Bacterial Agents
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Anti-HIV Agents
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Antineoplastic Agents, Phytogenic
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Plant Extracts