8-Amido-Bearing pseudomycin B (PSB) analogue: novel antifungal agents

Bioorg Med Chem Lett. 2001 Jan 22;11(2):123-6. doi: 10.1016/s0960-894x(00)00606-5.

Abstract

During the course of a structure-activity relationship (SAR) study on novel depsinonapeptide pseudomycin B, we synthesized a total of 12 8-amidopseudomycin analogues via standard two-step sequence from either ZPSB 2 or AllocPSB 3. A number of these amides exhibited good in vitro antifungal activities.

MeSH terms

  • Animals
  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Aspergillus fumigatus / drug effects
  • Candida albicans / drug effects
  • Candidiasis / drug therapy
  • Combinatorial Chemistry Techniques
  • Cryptococcus neoformans / drug effects
  • Dose-Response Relationship, Drug
  • Mice
  • Microbial Sensitivity Tests
  • Models, Animal
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptides, Cyclic / chemical synthesis
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antifungal Agents
  • Peptides, Cyclic
  • pseudomycin B