Altered striatal dopamine D2 receptor density and dopamine transport in a patient with hepatic encephalopathy

Metab Brain Dis. 2000 Sep;15(3):173-8. doi: 10.1007/BF02674526.

Abstract

A patient suffering from liver cirrhosis presented with a bradykinetic-rigid syndrome suspected as Parkinson's disease. A detailed work-up of the case revealed hepatic encephalopathy as the cause of the neurological symptomatology. An alteration of striatal dopamine D2 receptor binding and dopamine re-uptake sites was demonstrated by 123I-iodobenzamide (IBZM) and 123I-beta-CIT single photon emission computed tomography (SPECT), respectively. It is suggested that the alteration of the dopamine re-uptake in cirrhotics may be the cause of an increased catabolism of dopamine in HE.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Benzamides
  • Biological Transport
  • Case-Control Studies
  • Contrast Media / pharmacology
  • Dopamine / metabolism*
  • Dopamine / pharmacokinetics
  • Dopamine Antagonists / pharmacology
  • Hepatic Encephalopathy / diagnosis
  • Hepatic Encephalopathy / metabolism*
  • Hepatic Encephalopathy / pathology
  • Humans
  • Liver / pathology
  • Liver Cirrhosis / diagnosis
  • Liver Cirrhosis / metabolism
  • Liver Cirrhosis / pathology
  • Male
  • Middle Aged
  • Protein Binding
  • Pyrrolidines
  • Receptors, Dopamine D2 / metabolism*
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Benzamides
  • Contrast Media
  • Dopamine Antagonists
  • Pyrrolidines
  • Receptors, Dopamine D2
  • 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide
  • Dopamine