Abstract
Four patients affected by severe Parkinson's disease developed leucopenia (900-1200 WBC) during treatment of psychosis (3) or untreatable insomnia (1) with clozapine (37.5-75 mg/day). Clozapine withdrawal was followed by recovery of leucopenia (4000-6000 WBC) in two weeks with no need for the administration of leucokines. After 1-6 months olanzapine was administered (increasing the dose from 2.5 to 10 mg/day) to treat persisting disturbances, but the drug induced severe worsening of parkinsonism and also this drug had to be withdrawn.
MeSH terms
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Aged
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Aged, 80 and over
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Antipsychotic Agents / administration & dosage
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Antipsychotic Agents / adverse effects*
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Benzodiazepines
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Clozapine / administration & dosage
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Clozapine / adverse effects*
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Dose-Response Relationship, Drug
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Female
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Hallucinations / drug therapy
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Hallucinations / etiology
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Hallucinations / physiopathology
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Humans
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Leukopenia / chemically induced*
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Leukopenia / physiopathology
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Male
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Olanzapine
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Parkinson Disease / drug therapy*
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Parkinson Disease / physiopathology
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Parkinson Disease / psychology
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Pirenzepine / administration & dosage
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Pirenzepine / adverse effects*
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Pirenzepine / analogs & derivatives*
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Psychotic Disorders / drug therapy
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Psychotic Disorders / etiology
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Psychotic Disorders / physiopathology
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Sexual Dysfunctions, Psychological / drug therapy
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Sexual Dysfunctions, Psychological / etiology
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Sexual Dysfunctions, Psychological / physiopathology
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Sleep Initiation and Maintenance Disorders / drug therapy
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Sleep Initiation and Maintenance Disorders / etiology
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Sleep Initiation and Maintenance Disorders / physiopathology
Substances
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Antipsychotic Agents
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Benzodiazepines
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Pirenzepine
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Clozapine
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Olanzapine