Abstract
A novel C19 homolignan, taiwanschirin D (1), possessing a 3,4-(1-[(Z)-2-methoxy-2-oxoethylidenel)pentano (2,3-dihydrobenzo[b]furan)-3(2-oxoacetate) skeleton, was isolated from the stem of Kadsura matsudai Hayata. Its structure was determined from physical and spectral data including 2D NMR spectra. The Anti-HBeAg test revealed that taiwanschirin D (1) had moderate activity at a concentration of 94.3 microM (50 microg/ml).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Cell Survival / drug effects
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HeLa Cells
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Hepatitis B virus / drug effects
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Humans
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KB Cells
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Magnoliopsida / chemistry*
Substances
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Antineoplastic Agents
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Antiviral Agents
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Lignans
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taiwanschirin D