Abstract
We report here that glucagon-like peptide 2(GLP-2) and its receptor constitute a distinct projection system connecting the nucleus of the solitary tract with the dorsomedial hypothalamic nucleus (DMH). The DMH contains a dense plexus of GLP-2 immunoreactive fibres and is the only hypothalamic nucleus expressing GLP-2 receptor mRNA. Consistent with this, central application of GLP-2 activates the expression of neurones solely in the DMH. Furthermore, central administration of GLP-2 causes a dose-related, a pharmacologically and behaviourally specific inhibition of food intake in rats. Surprisingly, the alleged GLP-1 receptor antagonist, Exending (9-39), proved a functional antagonist of centrally applied GLP-2. These data implicate GLP-2 as an important neurotransmitter in the regulation of food intake and likely bodyweight. Our data therefore point to the DMH as a crossroad for endocrine and visceral information affecting feeding behaviour.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Appetite Regulation / drug effects
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Appetite Regulation / physiology*
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Brain Stem / immunology
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Brain Stem / metabolism
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Dorsomedial Hypothalamic Nucleus / immunology
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Dorsomedial Hypothalamic Nucleus / metabolism
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Gastrointestinal Hormones / administration & dosage
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Gastrointestinal Hormones / immunology
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Gastrointestinal Hormones / physiology*
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Gene Expression
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Glucagon-Like Peptide 1
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Glucagon-Like Peptide 2
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Humans
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Immunohistochemistry
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In Situ Hybridization, Fluorescence
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Neurotransmitter Agents / administration & dosage
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Neurotransmitter Agents / immunology
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Neurotransmitter Agents / physiology*
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Peptides / administration & dosage
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Peptides / immunology
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Peptides / physiology*
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RNA, Messenger / genetics
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Rats
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Rats, Wistar
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Receptors, Glucagon / genetics
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Receptors, Glucagon / immunology
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Receptors, Glucagon / physiology*
Substances
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Gastrointestinal Hormones
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Glucagon-Like Peptide 2
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Neurotransmitter Agents
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Peptides
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RNA, Messenger
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Receptors, Glucagon
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Glucagon-Like Peptide 1