BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

Nat Neurosci. 2001 Mar;4(3):233-4. doi: 10.1038/85064.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Aspartic Acid Endopeptidases / metabolism*
  • Cells, Cultured
  • Endopeptidases
  • Mice
  • Mice, Knockout / metabolism
  • Neurons / metabolism*

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • Bace1 protein, mouse