A flow injection chemiluminescence system for the determination of isoniazid

Y Huang; Z Zhang; D Zhang; J Lv

doi:10.1007/s002160000473

A flow injection chemiluminescence system for the determination of isoniazid

Fresenius J Anal Chem. 2000 Oct;368(4):429-31. doi: 10.1007/s002160000473.

Authors

Y Huang¹, Z Zhang, D Zhang, J Lv

Affiliation

¹ Institute of Analytical Sciences, Southwest Normal University, Beibei, PR China.

PMID: 11227519
DOI: 10.1007/s002160000473

Abstract

A chemiluminescence (CL) flow system is described for the determination of isoniazid based on its enhancement on the chemiluminescence (CL) emission produced upon mixing a hexacyanoferrate(III) solution with an alkaline luminol solution. The system responds linearly to isoniazid concentration in the range 0-1 mg/L with a detection limit (3sigma) of 0.03 microg/L, relative standard deviation (RSD) of 1.2% for 0.1 mg/L isoniazid (n = 11). The system has been successfully applied to the determination of isoniazid in pharmaceutical preparations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / analysis*
Antitubercular Agents / standards
Isoniazid / analysis*
Isoniazid / standards
Luminescent Measurements
Pharmaceutical Preparations / analysis
Pharmaceutical Preparations / standards
Reference Standards
Sensitivity and Specificity
Tablets / analysis

Substances

Antitubercular Agents
Pharmaceutical Preparations
Tablets
Isoniazid