Abstract
The past year has provided insight into the mechanisms by which multipotent progenitors commit to differentiation through the B lymphocyte lineage. Mice lacking the Pax5 gene develop pro-B lymphocytes but these cells are not uniquely committed to the B lineage as they can give rise to all hematopoietic cell types if cultured under appropriate conditions. Regulators of lymphocyte proliferation and survival have also been identified that may allow lymphocytes to respond to information provided by the external environment.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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B-Lymphocytes / cytology*
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B-Lymphocytes / metabolism*
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Basic Helix-Loop-Helix Transcription Factors
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Cell Lineage
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DNA-Binding Proteins / physiology
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Humans
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Lymphoid Enhancer-Binding Factor 1
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Nuclear Proteins / physiology
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PAX5 Transcription Factor
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Proto-Oncogene Proteins / physiology
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Trans-Activators / physiology
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Transcription Factors / physiology*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins
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EBF1 protein, human
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Lymphoid Enhancer-Binding Factor 1
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Nuclear Proteins
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PAX5 Transcription Factor
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PAX5 protein, human
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Proto-Oncogene Proteins
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TCF3 protein, human
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Trans-Activators
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Transcription Factors
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proto-oncogene protein Spi-1