Modified synthesis and antiangiogenic activity of linomide

S R Khan; A Mhaka; R Pili; J T Isaacs

doi:10.1016/s0960-894x(00)00699-5

Modified synthesis and antiangiogenic activity of linomide

Bioorg Med Chem Lett. 2001 Feb 26;11(4):451-2. doi: 10.1016/s0960-894x(00)00699-5.

Authors

S R Khan¹, A Mhaka, R Pili, J T Isaacs

Affiliation

¹ Johns Hopkins Oncology Center, Baltimore, MD 21205, USA. [email protected]

PMID: 11229745
DOI: 10.1016/s0960-894x(00)00699-5

Abstract

A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Angiogenesis Inhibitors / chemical synthesis*
Animals
Hydroxyquinolines / chemical synthesis*
Hydroxyquinolines / pharmacology
Mice

Substances

Angiogenesis Inhibitors
Hydroxyquinolines
roquinimex

Grants and funding

2P50CA5823607/CA/NCI NIH HHS/United States