Abstract
The expression of chemokine receptors on lymphocytes in the blood and CSF of multiple sclerosis (MS) patients was analyzed at relapse and remission. Both CD4+ and CD8+ cells in CSF at relapse were enriched for Th1-type receptors CXCR3 and CCR5 expression, and were reduced for Th2-type receptors CCR3 and CCR4 expression compared with those of the blood. CCR1 and CCR2 expressions on T cells were increased in CSF and blood, respectively. At remission, CCR5 expression, but not CXCR3 expression, was reduced in CSF CD4+ cells. A biased Th1/Th2 balance may play a critical role in active inflammation and CCR5 on CSF CD4+ cells is a good marker of the disease activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Biomarkers
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / metabolism
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CD8-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / metabolism
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Female
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Humans
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Male
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Multiple Sclerosis, Relapsing-Remitting / blood
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Multiple Sclerosis, Relapsing-Remitting / cerebrospinal fluid
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Multiple Sclerosis, Relapsing-Remitting / immunology*
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Receptors, CCR1
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Receptors, CCR2
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Receptors, CCR4
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Receptors, CCR5 / immunology
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Receptors, CCR5 / metabolism
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Receptors, CXCR3
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Receptors, Chemokine / immunology
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Receptors, Chemokine / metabolism*
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Recurrence
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Remission, Spontaneous
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Signal Transduction / immunology*
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Th1 Cells / immunology*
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Th1 Cells / metabolism
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Th2 Cells / immunology*
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Th2 Cells / metabolism
Substances
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Biomarkers
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CCR1 protein, human
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CCR2 protein, human
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CCR4 protein, human
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CXCR3 protein, human
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Receptors, CCR1
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Receptors, CCR2
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Receptors, CCR4
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Receptors, CCR5
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Receptors, CXCR3
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Receptors, Chemokine