Peroxisome proliferator-activated receptor gamma, the ultimate liaison between fat and transcription

Br J Nutr. 2000 Dec:84 Suppl 2:S223-7. doi: 10.1079/096582197388581.

Abstract

The peroxisome proliferator-activated receptor gamma (PPARgamma) is nuclear receptor that controls the expression of a large number of genes involved in adipocyte differentiation, lipid storage and insulin sensitization. PPARgamma is bound and activated by fatty acid derivatives and prostaglandin J2. In addition, thiazolidinediones, non-steroidal anti-inflammatory drugs are synthetic ligands and agonists of this receptor. This review addresses the role of PPARgamma in obesity and diabetes.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / metabolism*
  • Adipose Tissue / pathology
  • Cell Differentiation
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / pathology
  • Humans
  • Leptin / metabolism
  • Obesity / metabolism*
  • Obesity / pathology
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Thiazoles / metabolism
  • Thiazolidinediones*
  • Transcription Factors / physiology*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Leptin
  • Receptors, Cytoplasmic and Nuclear
  • Thiazoles
  • Thiazolidinediones
  • Transcription Factors
  • Tumor Necrosis Factor-alpha
  • 2,4-thiazolidinedione