Abstract
In multicellular organisms, the delivery of proteins to lysosomes is essential. Many of the genes necessary for this process have first been identified by their requirement for vacuolar delivery in yeast. A subset of these genes, the four class C vps genes, is necessary for the delivery of endocytic and biosynthetic cargo in yeast, and also in Drosophila. Here, we describe the sequence and expression pattern of four human homologs of these genes. This initial molecular description of these four genes is an important step towards their evaluation as candidate genes that may be involved in the pathogenesis of Hermansky-Pudlak syndrome-related diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Blotting, Northern
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Carrier Proteins / genetics*
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DNA, Complementary / chemistry
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DNA, Complementary / genetics
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Female
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Humans
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Membrane Proteins / genetics*
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Molecular Sequence Data
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Phylogeny
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Proteins / genetics*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Sequence Analysis, DNA
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Tissue Distribution
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Vesicular Transport Proteins*
Substances
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Carrier Proteins
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DNA, Complementary
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Membrane Proteins
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Proteins
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RNA, Messenger
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VPS11 protein, human
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VPS16 protein, human
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VPS18 protein, human
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VPS33A protein, human
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Vesicular Transport Proteins
Associated data
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GENBANK/AF308800
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GENBANK/AF308801
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GENBANK/AF308802
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GENBANK/AF308803