Novel filaments 5 nm in diameter constitute the cytosolic ring of the plastid division apparatus

Plant Cell. 2001 Mar;13(3):707-21. doi: 10.1105/tpc.13.3.707.

Abstract

The plastid division apparatus (called the plastid-dividing ring) has been detected in several plant and algal species at the constricted region of plastids by transmission electron microscopy. The apparatus is composed of two or three rings: an outer ring in the cytosol, an inner ring in the stroma, and a middle ring in the intermembrane space. The components of these rings are not clear. FtsZ, which forms the bacterial cytokinetic ring, has been proposed as a component of both the inner and outer rings. Here, we present the ultrastructure of the outer ring at high resolution. To visualize the outer ring by negative staining, we isolated dividing chloroplasts from a synchronized culture of a red alga, Cyanidioschyzon merolae, and lysed them with nonionic detergent Nonidet P-40. Nonidet P-40 extracted primarily stroma, thylakoids, and the inner and middle rings, leaving the envelope and outer ring largely intact. Negative staining revealed that the outer ring consists of a bundle of 5-nm filaments in which globular proteins are spaced 4.8 nm apart. Immunoblotting using an FtsZ-specific antibody failed to show immunoreactivity in the fraction containing the filament. Moreover, the filament structure and properties are unlike those of known cytoskeletal filaments. The bundle of filaments forms a very rigid structure and does not disassemble in 2 M urea. We also identified a dividing phase-specific 56-kD protein of chloroplasts as a candidate component of the ring. Our results suggest that the main architecture of the outer ring did not descend from cyanobacteria during the course of endosymbiosis but was added by the host cell early in plant evolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actin Cytoskeleton / chemistry
  • Actin Cytoskeleton / ultrastructure*
  • Arabidopsis Proteins
  • Cell Division
  • Chloroplasts / ultrastructure*
  • Cytosol / ultrastructure
  • Detergents
  • Electrophoresis, Polyacrylamide Gel
  • Negative Staining
  • Octoxynol
  • Phosphotungstic Acid
  • Plant Proteins / analysis
  • Polyethylene Glycols
  • Rhodophyta / ultrastructure*

Substances

  • Arabidopsis Proteins
  • Detergents
  • FTSZ protein, Arabidopsis
  • Plant Proteins
  • Phosphotungstic Acid
  • Polyethylene Glycols
  • Octoxynol
  • Nonidet P-40