HLA-A*01-restricted cytotoxic T-lymphocyte epitope from the Plasmodium falciparum circumsporozoite protein

A Kumar; S Kumar; T P Le; S Southwood; J Sidney; J Cohen; A Sette; S L Hoffman

doi:10.1128/IAI.69.4.2766-2771.2001

HLA-A*01-restricted cytotoxic T-lymphocyte epitope from the Plasmodium falciparum circumsporozoite protein

Infect Immun. 2001 Apr;69(4):2766-71. doi: 10.1128/IAI.69.4.2766-2771.2001.

Authors

A Kumar¹, S Kumar, T P Le, S Southwood, J Sidney, J Cohen, A Sette, S L Hoffman

Affiliation

¹ Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, USA. [email protected]

Abstract

Here, we report the identification of a novel CD8+ cytotoxic T-lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted by HLA-A*01 and is recognized by human volunteers immunized with irradiated P. falciparum sporozoites. HLA-A*01 is the second most common HLA allele among Caucasians.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Amino Acid Sequence
Animals
Epitopes, T-Lymphocyte*
HLA-A Antigens / genetics*
Humans
Immunization
Molecular Sequence Data
Peptide Fragments / immunology*
Plasmodium falciparum / immunology*
Protozoan Proteins / immunology*
T-Lymphocytes, Cytotoxic / immunology*

Substances

Epitopes, T-Lymphocyte
HLA-A Antigens
Peptide Fragments
Protozoan Proteins
circumsporozoite protein, Protozoan