X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor

MeSH terms

• Animals
• Benzamides / chemical synthesis*
• Benzamides / chemistry
• Benzamides / pharmacology
• Bone Resorption / drug therapy
• Bone and Bones / enzymology*
• Citric Acid / chemistry*
• Crystallography, X-Ray
• Cyclohexanes / chemical synthesis*
• Cyclohexanes / chemistry
• Cyclohexanes / pharmacology
• Durapatite / chemistry
• Enzyme Inhibitors / chemical synthesis*
• Enzyme Inhibitors / chemistry
• Enzyme Inhibitors / pharmacology
• Ligands
• Models, Molecular
• Molecular Mimicry
• Organophosphorus Compounds / chemical synthesis*
• Organophosphorus Compounds / chemistry
• Organophosphorus Compounds / pharmacology
• Osteoclasts / pathology
• Phosphotyrosine / chemistry
• Protein Binding
• Proto-Oncogene Proteins pp60(c-src) / antagonists & inhibitors
• Proto-Oncogene Proteins pp60(c-src) / chemistry*
• Rabbits
• src Homology Domains*