[Synthesis of 3-carbethoxi-2-phenyl-4-quinolones. Potential antimitotics]

Acta Cient Venez. 2000;51(3):137-42.
[Article in Spanish]

Abstract

The synthesis of the title compounds involved four main reactions: condensation between the acid chlorides and diethyl malonate to obtain the diethyl benzoylmalonates; transformation of these in diethyl chloroarylidenmalonates; the reaction of the substituted anilines with the chlorinated compounds and finally the thermal cyclization in diphenyl ether.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Colchicine / chemistry
  • Quinolines / chemical synthesis*
  • Quinolines / pharmacology*
  • Tubulin / metabolism

Substances

  • Antineoplastic Agents
  • Quinolines
  • Tubulin
  • Colchicine