Abstract
Novel inhibitors of bacterial tyrosyl tRNA synthetase have been synthesised in which the cyclic hydroxylamine moiety of SB-219383 is replaced by C-pyranosyl derivatives. Potent and selective inhibition of bacterial tyrosyl tRNA synthetase was obtained.
MeSH terms
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Bacterial Proteins / chemistry
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Bacterial Proteins / metabolism
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology
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Furans / chemistry*
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Furans / pharmacology
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Models, Molecular
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Molecular Structure
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Pyrans / chemistry*
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Staphylococcus aureus / enzymology
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Staphylococcus aureus / metabolism
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Tyrosine-tRNA Ligase / antagonists & inhibitors*
Substances
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Bacterial Proteins
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Bridged Bicyclo Compounds, Heterocyclic
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Enzyme Inhibitors
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Furans
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Pyrans
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SB 219383
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Tyrosine-tRNA Ligase