Effects of pH and metal ions on antioxidative activities of catechins

Biosci Biotechnol Biochem. 2001 Jan;65(1):126-32. doi: 10.1271/bbb.65.126.

Abstract

The Effects of pH on antioxidative activities of catechol, pyrogallol, and four catechins, and effects of metal ions (Al3+, Ca2+, Cd2+, Co2+, Cr3+, Cu2+, Fe2+, Fe3+, K+, Mg2+, Mn2+, Na+, and Zn2+) on antioxidative activities of (-)-epigallocatechin gallate (EGCG) were studied by an oxygen electrode method. The antioxidative activities of catechins were high and constant at pH 6-12, but decreased in acidic and strong alkaline solutions. Copper(II) ion the most strongly increased the antioxidative activity of EGCG among these metal ions examined, but iron(II) ion largely inhibited the antioxidative activity of EGCG. These effects are discussed considering the formation of metal complexes with catechins and the change in oxidation potentials.

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / metabolism
  • Antioxidants / pharmacology*
  • Catechin / analogs & derivatives
  • Catechin / chemistry
  • Catechin / metabolism
  • Catechin / pharmacology*
  • Catechols / chemistry
  • Catechols / metabolism
  • Catechols / pharmacology
  • Humans
  • Hydrogen-Ion Concentration
  • Linoleic Acid / metabolism
  • Metals / chemistry
  • Metals / metabolism
  • Metals / pharmacology*
  • Molecular Structure
  • Oxidation-Reduction
  • Pyrogallol / chemistry
  • Pyrogallol / metabolism
  • Pyrogallol / pharmacology
  • Tea / chemistry

Substances

  • Antioxidants
  • Catechols
  • Metals
  • Tea
  • Pyrogallol
  • Catechin
  • Linoleic Acid
  • gallocatechol
  • catechol