Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3641-3. doi: 10.1073/pnas.081082498.
No abstract available

Publication types

  • Comment
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acrocephalosyndactylia / genetics
  • Acrocephalosyndactylia / metabolism*
  • Animals
  • Disease Models, Animal
  • Fibroblast Growth Factors / metabolism
  • Humans
  • Ligands
  • Mice
  • Mutation
  • Phenotype
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Receptor, Fibroblast Growth Factor, Type 2
  • Receptors, Fibroblast Growth Factor / genetics
  • Receptors, Fibroblast Growth Factor / metabolism*
  • Signal Transduction

Substances

  • Ligands
  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors
  • FGFR2 protein, human
  • Fgfr2 protein, mouse
  • Receptor Protein-Tyrosine Kinases
  • Receptor, Fibroblast Growth Factor, Type 2