Abstract
The syntheses and antitumor activity of three paclitaxel-chlorambucil hybrids are presented. Hybrid 3 showed significant in vivo efficacy.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / therapeutic use
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Antineoplastic Agents, Alkylating / chemistry
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Antineoplastic Agents, Alkylating / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Chlorambucil / chemistry
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Chlorambucil / pharmacology
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Disease Models, Animal
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Female
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Humans
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Inhibitory Concentration 50
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Mice
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Neoplasm Transplantation
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Ovarian Neoplasms / drug therapy
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Paclitaxel / chemistry
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Paclitaxel / pharmacology
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Sarcoma / drug therapy
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Tumor Cells, Cultured
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Xenograft Model Antitumor Assays
Substances
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Antineoplastic Agents
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Antineoplastic Agents, Alkylating
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Antineoplastic Agents, Phytogenic
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Chlorambucil
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Paclitaxel