Abstract
The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aging / physiology*
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Alleles
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Animals
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Body Constitution
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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Crosses, Genetic
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Drosophila Proteins*
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Drosophila melanogaster / genetics
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Drosophila melanogaster / physiology*
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Female
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Fertility
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Genes, Insect
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Heterozygote
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Hot Temperature
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Insect Proteins / genetics*
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Insect Proteins / metabolism*
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Insulin / metabolism
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Insulin Receptor Substrate Proteins
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Intracellular Signaling Peptides and Proteins*
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Longevity / physiology*
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Male
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Mutation
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Oxidative Stress
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Protein-Tyrosine Kinases / genetics
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Protein-Tyrosine Kinases / metabolism
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Receptor Protein-Tyrosine Kinases*
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Receptor, Insulin / metabolism*
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Reproduction
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Signal Transduction
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Somatomedins / metabolism
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Starvation
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Superoxide Dismutase
Substances
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Carrier Proteins
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Drosophila Proteins
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Insect Proteins
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Insulin
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Insulin Receptor Substrate Proteins
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Intracellular Signaling Peptides and Proteins
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Somatomedins
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chico protein, Drosophila
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Superoxide Dismutase
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InR protein, Drosophila
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Protein-Tyrosine Kinases
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Receptor Protein-Tyrosine Kinases
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Receptor, Insulin