An improved method for the palladium-catalyzed amination of aryl iodides

M H Ali; S L Buchwald

doi:10.1021/jo0008486

An improved method for the palladium-catalyzed amination of aryl iodides

J Org Chem. 2001 Apr 20;66(8):2560-5. doi: 10.1021/jo0008486.

Authors

M H Ali¹, S L Buchwald

Affiliation

¹ Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

PMID: 11304171
DOI: 10.1021/jo0008486

Abstract

Aryl iodides are coupled with amines to give the corresponding arylamines in high yield in the presence of palladium, a suitable ligand, and NaOt-Bu. Functionalized aryl iodides give good yields of the corresponding arylamines when Cs(2)CO(3) is substituted as the base.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Amines / chemical synthesis*
Catalysis
Hydrocarbons, Aromatic / chemistry*
Iodides / chemistry
Ligands
Palladium

Substances

Amines
Hydrocarbons, Aromatic
Iodides
Ligands
Palladium

Grants and funding

GM58160/GM/NIGMS NIH HHS/United States