Indenopyrazoles as novel cyclin dependent kinase (CDK) inhibitors

J Med Chem. 2001 Apr 26;44(9):1334-6. doi: 10.1021/jm0100032.

Authors

D A Nugiel¹, A M Etzkorn, A Vidwans, P A Benfield, M Boisclair, C R Burton, S Cox, P M Czerniak, D Doleniak, S P Seitz

Affiliation

¹ The DuPont Pharmaceuticals Company, Box 80336, Wilmington, Delaware 19880-0336, USA.

PMID: 11311054
DOI: 10.1021/jm0100032

No abstract available

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Cyclin-Dependent Kinases / antagonists & inhibitors*
Drug Screening Assays, Antitumor
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Humans
Mice
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry
Pyrazoles / pharmacology
Structure-Activity Relationship
Transplantation, Heterologous
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Enzyme Inhibitors
Pyrazoles
Cyclin-Dependent Kinases