Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type 1 (HIV-1) p24gag epitope by HIV-1-infected children

F Buseyne; M L Chaix; C Rouzioux; S Blanche; Y Rivière

doi:10.1128/JVI.75.10.4941-4946.2001

Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type 1 (HIV-1) p24gag epitope by HIV-1-infected children

J Virol. 2001 May;75(10):4941-6. doi: 10.1128/JVI.75.10.4941-4946.2001.

Authors

F Buseyne¹, M L Chaix, C Rouzioux, S Blanche, Y Rivière

Affiliation

¹ Laboratoire d'Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Hôpital Necker-Enfants Malades, 75015 Paris, France. [email protected]

Abstract

We tested seven human immunodeficiency virus-infected children for their cytotoxic T-lymphocyte (CTL) activities towards the p24gag QASQEVKNW epitope and its nine variant sequences. Our data confirm that most, but not all, CTL responses are broadly cross-specific. For the first time, we show the high interpatient variability in cross-recognition of mutant CTL epitopes. These interindividual variations in the CTL response to the same epitope should be taken into account in the design and the evaluation of vaccines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child
Cross Reactions
Epitopes, T-Lymphocyte / immunology*
Genetic Variation*
HIV Core Protein p24 / immunology*
HIV Infections / immunology
HIV Infections / virology*
HIV-1 / classification
HIV-1 / immunology*
HLA Antigens / immunology
HLA-B Antigens / immunology
Humans
Leukocytes, Mononuclear / immunology
Lymphocyte Activation
T-Lymphocytes, Cytotoxic / immunology*

Substances

Epitopes, T-Lymphocyte
HIV Core Protein p24
HLA Antigens
HLA-B Antigens
HLA-B53 antigen
HLA-B57 antigen