Loss of heterozygosity or intragenic mutation, which comes first?

Am J Pathol. 2001 May;158(5):1561-3. doi: 10.1016/S0002-9440(10)64109-0.
No abstract available

Publication types

  • Comment
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes, Human, Pair 17 / genetics
  • Chromosomes, Human, Pair 18 / genetics
  • DNA-Binding Proteins / genetics
  • Humans
  • Loss of Heterozygosity*
  • Microsatellite Repeats
  • Mutation*
  • Pancreatic Neoplasms / genetics
  • Pancreatic Neoplasms / pathology
  • Smad4 Protein
  • Trans-Activators / genetics
  • Tumor Suppressor Protein p53 / genetics

Substances

  • DNA-Binding Proteins
  • SMAD4 protein, human
  • Smad4 Protein
  • Trans-Activators
  • Tumor Suppressor Protein p53