Abstract
A novel series of potential antipsychotic agents were prepared by combination of condensed heterocycles containing bridgehead nitrogen with (2-methoxyphenyl)piperazine using phenoxyalkyl spacer of variable length. The affinity of the compounds was determined at rat cloned D3 and rat D2, 5-HT1A receptors by an vitro receptor binding assay. The D3 selectivity of the compounds was calculated from the Ki values.
MeSH terms
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Animals
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Binding, Competitive / drug effects
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Dopamine Agents / chemical synthesis*
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Dopamine Agents / pharmacology*
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Hippocampus / drug effects
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Hippocampus / metabolism
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Kinetics
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Ligands
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Neostriatum / drug effects
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Neostriatum / metabolism
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Piperazines / chemical synthesis*
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Piperazines / pharmacology*
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Rats
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Receptors, Dopamine D2 / drug effects*
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Receptors, Dopamine D3
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Receptors, Serotonin / drug effects
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Receptors, Serotonin, 5-HT1
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Serotonin Agents / chemical synthesis
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Serotonin Agents / pharmacology
Substances
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Dopamine Agents
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Drd3 protein, rat
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Ligands
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Piperazines
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Receptors, Dopamine D2
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Receptors, Dopamine D3
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT1
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Serotonin Agents